What is going to help you choose the right Hotel is going to partially depend on the reason you are staying there. For example, if you are on a business trip then you will have different requirements as what a family would that is on vacation.
Assuming that your Hotel stay is going to be for vacation purposes there are some basics that you are really going to want to insist on. With a family you are going to want to be sure that you have a spacious room. You may require extra sleeping accommodations like a crib or a day bed. Check to see if these are provided by the Hotel and if there is any extra cost to these.
If your pet is travelling with you then this is something else that you will need to consider. You will only be able to use pet friendly Hotels. Check some of these out at the destination you are going to and see if there are size restrictions or any other rules concerning them.
Chances are if you have children you are going to want to have food facilities on the premises. Check these out before hand to be sure that there are some there and what kind of dining that they offer. Most often with the kids you are going to be more prone to family dining as opposed to fine dining.
Amenities is going to be important especially for the kids. If you end up being stuck in your Hotel accommodations because of inclement weather you want a Hotel that has some indoor activities for the kids. At the very least you will want a Hotel with an indoor swimming pool.
Make sure you do your research about each Hotel that you are considering. Not only do you want to check out their website but also take a look at some independent reviews to see how they have been rated.
Location may be important to you so check to see if the location of the Hotel works conveniently with the rest of your plans for visiting this area.